Abstract

The enantioselective total synthesis of the diyne containing natural products panaxytriol and (3 S,10 R)-panaxydiol from l-tartaric acid is reported. Key steps in the synthesis include the elaboration of a γ-hydroxy amide derived from tartaric acid to the required alkyne and the formation of the desired diyne unit by a Cadiot–Chodkiewicz coupling.

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