Abstract
Abstract The enantioselective total synthesis of micropine, an unusual 2,6-disubstituted piperidine alkaloid, and epimicropine, through mercuric trifluoroacetate-catalysed intramolecular alkenylamide cyclisation is described. The synthesis proceeds from L -serine and affords material of the same positive sign of optical rotation as the natural product thereby confirming the absolute stereochemistry of micropine.
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