Abstract
The cyanobacterial isolate largazole embodies a compelling combination of a relatively simple, yet unique cyclic depsipeptide structure with remarkable levels of selective cytotoxicity against cancer cell lines versus nontransformed cells. The unique structure of largazole inspired a strategically novel and aggressive approach towards its expedient total synthesis. This involved an initial dissection into an epoxy aldehyde and an unprotected tetrapeptide, representing the polyketide and polypeptide domains of largazole, respectively. These fragments were successfully joined using NHC-mediated amidation, but subsequent assembly of the cyclic depsipeptide via lactonization was thwarted. A reordering of key couplings led to a successful assembly of largazole.
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