Abstract

A concise total synthesis of (-)-ilicicolin H was efficiently achieved in 9 steps from commercially available (S)-(-)-citronellol. Key steps include a strategic convergent method to synthesize the densely substituted pyridone key intermediate by Suzuki-Miyaura cross-coupling reaction, a facile construction of polyene fragment through a regioselective Wittig olefination and construction of the decalin moiety via IMDA. Herein, we describe our efforts towards the synthesis of (-)-ilicicolin H..

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