Abstract
A simple, short, efficient, and concise approach for the synthesis of decytospolides A, B and partial synthesis of aspergillide A was achieved from d-mannitol. The key steps employed in this approach are a Barbier type allylation, an epoxide opening by Grignard reagent, a chelation controlled reduction, tandem or domino (olefin cross-metathesis/intramolecular oxa-conjugate cyclization by Hoveydas–Grubb’s 2nd generation and olefin cross-metathesis/SN2 reaction with Grubb’s 2nd generation catalyst) processes.
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