Abstract
The construction of the BCD-ring system of C 19-diterpene alkaloids was initiated by development of a ring expansion reaction of cyclic enamino-esters with propiolic acid esters, leading from the 5-membered ring ketone 3 to the 7-membered ring ketone 10. Epoxidation and stereospecific reductive epoxide ring opening to give hydroxy ester 18 were subsequent key-steps which eventually furnished cyclic β-keto ester 22. This versatile intermediate has a full potential of functional groups suited for further elaboration into the A-, E- and F-rings and substituents of a variety of C 19-diterpene alkaloids.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
