Total Synthesis in the Trost Laboratories: Selected Milestones From the Past Twenty Years

Abstract

AbstractSince the early days of his independent career, Prof. Barry M. Trost has maintained a keen interest in complex molecule synthesis. Over the past 55 years, Trost and coworkers have reported syntheses of more than 260 natural products, pharmaceuticals, and other complex biomolecules – a truly extraordinary feat and an incredible testament to Prof. Trost's inventiveness and ingenuity. Even more remarkably, Trost generated more than half of this output – as well as some of his most daring and ambitious syntheses – in just the past twenty years. This review provides a brief summary of all total syntheses from the Trost laboratories since 2000, as well as more detailed vignettes of sixteen particularly notable campaigns, including conquests of callipeltoside A, galanthamine and three related alkaloids, agelastatin A, terpestacin, pseudolaric acid B, ushikolide A, bryostatin 16, laulimalide, aeruginosin 98B, lasonolide A, perophoramidine, leustroducsin B, des‐epoxy‐amphidinolide N, bulleyanaline and three related alkaloids, and bryostatin 3.