Abstract
Heronapyrroles A and B with promising and selective antibacterial activity but no cytotoxicity against mammalian cell lines are among members of rare and unique 4-farnesylated-2-nitropyrrole natural products. The absolute configurations at C7 and C15 have been proposed to be 7S and 15R by the modified Mosher method. In this Letter, we have achieved the total synthesis of natural (+)-heronapyrroles A (1) and B (2) and report that the correct absolute configurations are 7R, 8S, and 15S as shown in the structural formulas 1 and 2.
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