Abstract
Velutone F (1), a natural bioactive chalcone isolated from Millettia velutina Dunn, possesses significant anti-inflammatory activity. In this study, we have accomplished the total synthesis of velutone F (1), along with its analogues 2 and 3, from a common starting material cyclohexandione in 5 to 7 steps. The anti-inflammatory activities of compounds 1 to 3 were determined against nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells and all of them exhibited different levels of anti-inflammatory activity.
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