Abstract
A highly stereocontrolled total synthesis of (-)-yaequinolone J1 and (+)-yaequinolone J2 was accomplished using an Evans auxiliary to establish a syn-diol unit in an acyclic appendage to a preformed benzopyran core bearing a homoprenyl group. The first total synthesis of a complex member of this family of 3,4-dioxygenated 3,4-dihydro 4-aryl quinolin-2-(1 H)-ones also allowed the assignment of absolute stereochemistry, thereby suggesting the same for several members of this family of biogenetically related alkaloids hitherto reported with relative configurations of stereogenic carbons for some and absolute assignments relying on empirical data for others.
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