Total Syntheses of Useful Bioactive Compounds

Abstract

The first total syntheses of a variety of useful bioactive compounds have been accomplished by practically useful strategies. In addition practically useful intermediates have been developed, analogues of natural products have been prepared, their structure-activity relationships studied, and the large-scale preparations of medically useful compounds established. The target molecules are antibiotics, antifungals, antitumor antibiotics, compounds related to β-lactam antibiotics, enzyme inhibitors, central nervous system-affecting products, non-steroidal progesterone receptor ligands, mussel-attachment inhibitors, and so on.