Abstract
Sesquiterpenoids (+)- trans-dracuncuflifoliol ( 1 ) and (+)-4-hydroxyoppositan-7-one ( 2 ) were prepared stereoselectively from enantiomerically pure (7a R)-7a-methyl-1,2,5,6,7,7a-hexahydro-4 H-inden-4-one ( (−)- 6 ), whose synthesis was described herein. Conjugate addition of the organocopper (I) reagent 10 to (−)- 6 , followed by epimerization of the ring junction, generated 3 of the 4 contiguous chiral centers of both natural products.
Published Version
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