Total Syntheses of (+)‐Cylindricines C—E and (‐)‐Lepadiformine Through a Common Intermediate Derived from an aza‐Prins Cyclization and Wharton′s Rearrangement.

Abstract

Enantioselective total syntheses of (+)-cylindricines C−E and (−)-lepadiformine through a common tricyclic intermediate are described here. These syntheses are concise and feature an aza-Prins cyclization and a seldom-used Wharton rearrangement en route to the common intermediate.