Abstract
The sulfhydryl concentration in the central nucleus of rat and mouse lenses falls precipitously with age. However in the lenses of man and water buffalo, the sulfhydryl decreases at a much slower rate with age. This difference between the two groups appears to be correlated with the derivation of albuminoid: in the rodents it is chiefly γ-crystallin which gives rise to albuminoid while in human and bovine lenses albuminoid is related to α-crystallin. The sulfhydryl concentration profiles along the visual axis of human, rabbit and chicken lenses of several ages show that these species have profiles unlike those of rat and mouse lenses; the rabbit lens is more like the human lens while the chicken lens is in a class by itself due to the predominance of δ-crystallin in the nucleus and the consequent extremely low concentration of sulfhydryl. The implications of these findings are discussed in relation to changes in the aging lens.
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