Abstract
In Aga Khan University, a retrospective review was conducted from January 2013-December 2020 for patients who received Total Skin Electron Beam Therapy (TSEBT) for the management of Mycosis Fungoides (MF). The clinical response rate and disease-free interval (DFI) was evaluated for three patients. All of the patients received a 3600 cGy dose of radiation. Clinical complete remission (cCR) was observed in two out of three patients, while one patient showed clinical partial response. Following the cCR to TSEBT, the DFI of the first patient with stage 1B lasted 30 months, while the second patient with stage IIB remained disease free for five months. TSEBT is an effective treatment for MF disease. It can thus be expected that patients with limited disease in the early stage can acquire a cCR with a longer DFI. ---Continue
Highlights
For the management of Mycosis Fungoides (MF)
Total Skin Electron Beam Therapy (TSEBT) is an effective treatment for MF disease
It can be expected that patients with limited disease in the early stage can acquire a Clinical complete remission (cCR) with a longer diseasefree interval (DFI)
Summary
Radiation involves the whole skin surface to be treated with the low energy electrons, produced by a linear accelerator to a specified depth. In current literature, this technique is referred to as total skin electron beam (TSEBT) therapy.[2] In contrast to conventional radiotherapy techniques, the patient is treated in a standing position with wide electron fields which are attained by the extended source to the skin distance (SSD). The most notable American series of TSEBT is from Stanford.[4] In these case series, the clinical response rate and disease-free interval of MF patients treated with TSEBT are being described. Consent was taken from the patients for publishing their cases
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