Abstract
The State’s Cocó Park in the city of Fortaleza-CE present mainly a mangrove flora and include landscape and medicinal plants. The aim of this study is determining the total phenol content, antioxidant activity against the free radical DPPH and the inhibition of the enzyme acetylcholinesterase (AChE) in ethanolic extracts of 30 medicinal plants and thus assess which plants have potential against Alzheimer's Disease. The plants rich in phenolic compounds with amounts ranging from 297.46 ± 26.94 to 599.30 ± 17.08 mg GAE/g plant extract, which showed greater antioxidant activities (with IC50 against DPPH radical from 3.44 ± 0.16 to 3.73 ± 0.12 µg mL-1) and higher acetylcholinesterase inhibiting power (IC50 < 20 μg mL-1) were Anacardium occidentale, Ceiba pentandraLaguncularia racemosa, Mangifera indica, Myracrodrum urundeuva and Terminalia catappa. Then, these species and their constituents are recommended for more specific studies related to Alzheimer´s Disease.
Highlights
The park bordering the Cocó river occupies an environmental conservation area containing 1,571.29 hectares, making it the largest natural park in an urban area in North/Northeast Brazil and the fourth in Latin America
Oxidative stress is an imbalance of free radicals and antioxidants in the body, which occurs naturally and plays a role in the aging process and it is related to many diseases such as cardiovascular diseases, acute and chronic kidney disease, neurodegenerative diseases, macular degeneration, biliary diseases, and cancer
This study aims to determine the total phenolic content, antioxidant activity and the inhibition of the enzyme acetylcholinesterase of medicinal plants present in the State’s Cocó Park in Fortaleza, Ceará and elaborate a bibliographic survey on the activities reported for plants, to try to correlate with the activities determined in order to discover new herbal agents with potential to be used in the treatment of Alzheimer's Disease (AD)
Summary
The park bordering the Cocó river occupies an environmental conservation area containing 1,571.29 hectares, making it the largest natural park in an urban area in North/Northeast Brazil and the fourth in Latin America. Consisting mainly of mangroves, the park is a haven for the city's fauna. The State’s Cocó Park besides offering leisure and tourist attractions, gives the opportunity for the elaboration of scientific researches. Oxidative stress is an imbalance of free radicals and antioxidants in the body, which occurs naturally and plays a role in the aging process and it is related to many diseases such as cardiovascular diseases, acute and chronic kidney disease, neurodegenerative diseases, macular degeneration, biliary diseases, and cancer. There is a close relationship between oxidative stress, inflammation, and aging (Liguori et al, 2018). Oxidative stress is involved in the development of several human pathologies, such as hypertension, atherosclerosis, asthma, cancer, rheumatoid arthritis, cataracts, diabetes mellitus and degenerative diseases (sclerosis multiplies, Parkinson's disease and Alzheimer's disease) (Phaniendra et al, 2015). Several studies have linked plant antioxidants with AChE inhibition and opened up several treatment options for AD (Akram & Nawaz, 2017; Penido et al, 2017)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
