Total Oxidant and Antioxidant Status in Patients with Obstructive Sleep Apnea and the Effect of Continuous Positive Airway Pressure

Abstract

Objective We explored total oxidant status (TOS) and total antioxidant status (TAS) in patients with obstructive sleep apnea (OSA) and compared them between patients and control group. We also evaluated the effect of continuous positive airway pressure (CPAP) treatment on oxidative stress parameters. Methods A total of 150 consecutive patients admitted to the sleep clinic for OSA evaluation between 2009 and 2013 were enrolled in the study, including 119 OSA patients and 31 simple snoring control subjects, confirmed by polysomnography. In both groups, serum TAS and TOS levels were measured. TAS and TOS levels of 16 patients in the OSA group were evaluated after CPAP titration. Results The OSA group consisted of 35 mild, 29 moderate, and 56 severe OSA patients. There was no association between the severity of sleep apnea and parameters of oxidative stress. No significant difference was found in serum TAS and TOS levels of the OSA group and the controls or before and after CPAP titration in 16 OSA patients. Conclusion In this study, we found no differences in oxidative stress parameters between control and OSA groups. A single night of CPAP treatment does not seem to influence the oxidant-antioxidant status in OSA. Keywords: Sleep apnea; Obstructive; Oxidative stress; Continuous positive airway pressure; Oxidants; Antioxidants