Abstract
Introduction: Surgical resection with curative intent followed by adjuvant chemotherapy is still the standard of care in pancreatic cancer (PC). Neoadjuvant chemotherapy is more and more administered to borderline-resectable (BR) and locally advanced (LA) PC with achievement of higher percentage of resectability and improvement of oncological outcomes. Currently, total neoadjuvant therapy (TNT), intended as induction chemotherapy (IC) followed by radiochemotherapy (RCT), has been taking hold. Aim of this review is to summarize the available evidence on the role of TNT.
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