Abstract
Todetermine whether local excision (LE) outcomes were comparable to total mesorectal excision (TME) outcomes in node-positive (cN+) rectal cancer patients who were good responders. This retrospective study included clinical T2-3 and cN+low rectal cancer patient who received preoperative chemoradiotherapy (PCRT) followed by TME or LE. Clinical stage T1 or T4 tumors, upper-to-middle rectal tumors (>7cm from anal verge), and synchronous distant metastases were excluded. Lymph nodes ≥5mm in size were defined as tumor-positive, and patients with metastatic lymph nodes >20mm in size were excluded. Preoperative chemoradiotherapy comprised radiation (50-50.4Gy/25-28 fractions over 5weeks) with 2 cycles of 5-fluorouracil or oral capecitabine. Propensity scores were computed from tumor and patient variables and used for 1-to-1 matched analysis. Local recurrence-free survival, disease-free survival, and overall survival were compared between the 2 matched groups. Between January 2007 and December 2013, 563 and 55 patients underwent TME and LE, respectively. The median follow-up period was 54months. In propensity score-matched analysis, 48 patients were included in each group. No statistical differences were observed in 3-year local recurrence-free survival (97.9% vs 97.9%, P=.994), 3-year disease-free survival (91.5% vs 91.4%, P=.968), or 3-year OS (93.7% vs 97.9%, P=.809) between the TME and LE groups. In clinical N+ rectal cancer patients, oncologic outcomes of PCRT followed by LE were comparable to those of TME; this finding might be applicable only to those patients with good response in the primary tumor and small lymph node metastases.
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More From: International Journal of Radiation Oncology, Biology, Physics
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