Abstract
Total intensity and quasielastic light scattering (QELS) techniques have been used to examine the effect of electrolyte on the micellar properties of the antidepressant drug imipramine hydrochloride in aqueous solution. A progressive increase of aggregation number and micellar radius was observed with increase of sodium chloride concentration over the range 0.05 to 0.6 M. A marked decrease of the diffusion coefficient with increase of drug concentration at concentrations just in excess of the critical micelle concentration has been noted and discussed. QELS measurements of the drug trimetaphan camphorsulfonate, which exhibits continuous association, showed a complex variation of effective diffusion coefficient with drug and electrolyte concentration.
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