Abstract
In previous studies it was observed a decrease in body weight, weight gain and in total T CD5+cells, T subpopulations and IgA containing B cells in the intestinal villi of rats fed a cereal based diet. Also, total IgA in intestinal fluids was diminished. The aim of this work is to study total IgA in the saliva of growing rats fed a low quality ‐ low concentration protein diet. Wistar rats were fed a 6.5% precooked maize diet for 18 days (M). Age‐matched quality control group received a 6.5% casein diet (Cas). Well‐nourished control group fed a 20% casein diet (C). Saliva was collected after stimulation with 1% pilocarpine. Total IgA concentration were determined by ELISA (BETHYL). Statistical analysis: ANOVA test. Results (X±SD, n=14‐17/group): Total IgA in saliva (mg/ml) in M was decreased compared to Cas and C (M:0.003±0.001 vs Cas:0.007±0.004; C:0.011±0.009, p<0.001). The results show that the intake of a low quality dietary protein produces a significant reduction in total IgA in saliva, which would demonstrate a disorder in the mucosal immunity. It suggests the importance of assessing secretory immunoglobulin A in non‐invasive samples, as saliva, in nutritional studies. Supported by UBACYT B098
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