Abstract
Background and aimsHigh-density lipoprotein (HDL) cholesterol efflux capacity in adults may be a measure of the atheroprotective property of HDL. Little however, is known about HDL cholesterol efflux capacity in childhood. We aimed to investigate the relationship between HDL cholesterol efflux capacity and childhood anthropometrics in a longitudinal study. Methods and resultsSeventy-five children (mean age = 9.4 ± 0.4 years) were followed from birth until the age of 9 years. HDL cholesterol efflux capacity was determined at age 9 by incubating serum-derived HDL-supernatants with 3H-cholesterol labeled J774 macrophages and percentage efflux determined. Mothers provided dietary information by completing food frequency questionnaires in early pregnancy and then 5 years later on behalf of themselves and their children. Pearson's correlations and multiple regression analyses were conducted to confirm independent associations with HDL efflux.There was a negative correlation between HDL cholesterol efflux capacity and waist circumference at age 5 (r = −0.3, p = 0.01) and age 9 (r = −0.24, p = 0.04) and BMI at age 5 (r = −0.45, p = 0.01) and age 9 (r = −0.19, p = 0.1). Multiple regression analysis showed that BMI at age 5 remained significantly associated with reduced HDL cholesterol efflux capacity (r = −0.45, p < 0.001).HDL-C was negatively correlated with energy-adjusted fat intake (r = −0.24, p = 0.04) and positively correlated with energy-adjusted protein (r = 0.24, p = 0.04) and starch (r = 0.29, p = 0.01) intakes during pregnancy. HDL-C was not significantly correlated with children dietary intake at age 5. There were no significant correlations between maternal or children dietary intake and HDL cholesterol efflux capacity. ConclusionsThis novel analysis shows that efflux capacity is negatively associated with adiposity in early childhood independent of HDL-C.
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