Abstract
To investigate the relationship between serum complement and the development of jaundice after liver transplantation, serial measurements of total serum haemolytic complement have been made in four patients during the 1st month after operation. In two cases, abnormally low levels were found during episodes of jaundice, shown to be attributable to rejection on histological grounds and on the results of leucocyte migration studies carried out concomitantly. In contrast, high levels of total serum haemolytic complement were found in the other two cases when liver function had deteriorated secondary to cholangitis and extrahepatic obstruction, respectively. The relevance of these findings to the differential diagnosis of jaundice after liver transplantation is discussed and related to serum complement levels in 95 other patients with various acute and chronic liver disorders.
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