Abstract
Objective: Iler is an ornamental plant that can be used as a medicinal plant. An effort to increase the flavonoids content was done by planting Iler in the lowlands with the hope that it can increase the secondary metabolites contained to meet the needs of flavonoids obtained from nature.
 Methods: This research was conducted in Tegal Gedhe Village, Karanganyar Regency with an altitude of 182 m above sea level with Brown Mediterranean soil types. The study used a completely randomized block design. The treatment used consists of one factor which was four accessions of iler plants. Analysis of iler extract was done using ethanol, while analysis of thin layer chromatography (TLC) used the n-hexane:ethyl acetate (6:4) and analysis of total flavonoid were used the AlCl3 method using a spectrophotometer.
 Results: The total extract content of iler plant in this study was not significantly different, which was accession 1 by 4.009% (±0.36), accession 2 by 5.677% (±0.25), accession 3 by 6.892% (±0.83), and accession 4 by 5.913% (±0.57). TLC analysis shows that accession 1 and accession 2 had 8 spots, while accession 3 and accession 4 formed 9 spots. The highest total flavonoid content was found in accession 2 (5.848% [±0.25]).
 Conclusion: Accession 2 has a better morphology such as wider leaves characterized by higher source of flavonoids and longer vegetative life than the other three accessions.
Highlights
Iler (Coleus atropurpureus) is a plant that is propagated and commonly grows tropical area
This study aims to determine the flavonoid content of four accessions of iler plants grown in the lowlands
In line with the research conducted by Alen et al [10] in their study, it was stated that in thin layer chromatography (TLC) analysis of bamboo shoot extract (Schizostachyum brachycladum Kurz [Kurz]) on UV 255 and 366 nm showed the same Rf value
Summary
Iler (Coleus atropurpureus) is a plant that is propagated and commonly grows tropical area. The main utilization of iler plants is a medicinal material which contains flavonoids that can be used as an alternative in the development of herbal plants in the world. Iler plants produce secondary metabolites in the form of steroids. In one research [1], pure isolates of steroids were obtained in the form of crystal needles with clear white color. The results of tests carried out using Liebermann–Burchard reagent resulted in the appearance of a green ring shape, indicating that secondary metabolites were found to be positive for steroids. The research of Lisdawati et al [2] stated that iler plants contained a class of chemical compounds in the form of terpenoids, tannins, catechin tannins, and flavonoids. Flavonoids can be used as prevention for cancer and coronary heart disease [4]
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