Total flavones of Hippophae rhamnoides L. for essential hypertension: a systematic review of randomized controlled trials

Abstract

Objective: To explain the change of postprandial serum triglyceride levels after a single high-fat meal (800 calories 50 g fat), and to investigate the relationship between postprandial serum triglyceride levels and artery elasticity. Methods: 34 patients with essential hypertension and 34 healthy controls were studied .The concentration of triglyceride, total cholesterol, LDL cholesterol, and HDL cholesterol in fasting serum and at 4 h after a single high-fat meal were measured. There were 13 patients with essential hypertension and 16 healthy controls which had postprandial hypertriglyceridemia (TG>1.7 mmol/L), others had normal postprandial serum triglyceride levels .Small and large artery elasticity was assessed in the brachial artery by the HDI/ Pulse wave CR-2000 Research Cardiovascular Profiling Systems before and after 4 h of high-fat meal. Result: No significant difference in fasting lipid levels among two subjects was found. Compared to normal subjects the patients with hypertension had higher serum triglyceride levels at 4 h (p<0.05), the postprandial small artery elasticity impaired significantly after a high-fat meal in postprandial hypertriglyceridemia groups (p<0.05) both patients and controls. There is no obvious change between two groups of subjects on large artery elasticity with postprandial. The postprandial artery elasticity was more serious in essential hypertension patients with postprandial hypertriglyceridemia. Conclusions: The 4 hour serum triglyceride level was correlated with the degree of impairment of postprandial artery elasticity. An obvious and persistent postprandial hypertriglyceridemia in patients induced significantly impairment of postprandial artery elasticity.