Abstract
Total effective vascular compliance, hemodynamic parameters, cardiopulmonary (CPBV) and total blood volumes (TBV) were determined in 31 men, including nine normotensive controls and 22 permanent essential hypertensive patients. The effective compliance was calculated from the changes in central venous pressure recorded simultaneously with the changes in blood volume obtained after a rapid dextran infusion. In hypertensives, compliance was significantly reduced (1.55 ± 0.6 vs 2.25 ± 0.11 ml./mm. Hg/Kg. in controls) (P < 0.001) and negatively correlated with blood pressure (P < 0.01), cardiac index (P < 0.01), and the CPBV/TBV ratio (P < 0.01). These results suggest that venous compliance contributes to the control of cardiac output in essential hypertension.
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