Abstract
Objective: To examine the association between serum total cholesterol at baseline and the risk of Parkinson disease (PD). Methods: Study cohorts included 24,773 Finnish men and 26,153 women aged 25 to 74 years without a history of PD and stroke at baseline. Hazard ratios (HRs) of incident PD were estimated for different levels of total cholesterol. Results: During a mean follow-up period of 18.1 years, 321 men and 304 women developed incident PD. After adjustment for confounding factors (age, study years, body mass index, systolic blood pressure, education, leisure-time physical activity, smoking, alcohol consumption, coffee and tea consumption, and history of diabetes), the HRs of PD at different levels of total cholesterol ( Conclusion: This large prospective study suggests that high total cholesterol at baseline is associated with an increased risk of Parkinson disease. GLOSSARY: AD = Alzheimer disease; BMI = body mass index; HR = hazard ratio; MONICA = Monitoring Trends and Determinants of Cardiovascular Disease; PD = Parkinson disease; WHO = World Health Organization.
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