Abstract
BackgroundEstimation of total body water (TBW) is essential for clinical care.ObjectiveEvaluation of changes in TBW by bioelectrical impedance analysis (BIA) in children and young adults with excessive weight.DesignData was collected in individuals aged 3–21 years with normal (n = 202) or excessive body weight (n = 133). The BIA results from individuals with normal weight were compared with two previously published studies in children by isotope dilution methods.ResultsIndividuals with excessive weight had a higher mean TBW (27.87 L, SE 0.368) for height and age as compared to individuals with normal weight (23.95 L, SE 0.298), P<0.001. However, individuals with excessive weight had lower mean TBW (24.93 L, SE 0.37) for weight and body surface area (BSA) as compared to individuals with normal weight (26.94 L, SE 0.287), P<0.001. Comparison with two previously published studies showed no significant differences in mean TBW with one ((p = 1.00) but a significant difference with another study (p = 0.001).ConclusionsIndividuals with excessive weight had 16.5% higher mean TBW for height and age and 7.4% lower TBW for weight and BSA as compared to normal weight individuals. Our study validates the feasibility of data collection in pediatric outpatient setting by BIA.
Highlights
Estimation of total body water (TBW) is integral to clinical care
Comparison with two previously published studies showed no significant differences in mean TBW with one ((p = 1.00) but a significant difference with another study (p = 0.001)
Individuals with excessive weight had 16.5% higher mean TBW for height and age and 7.4% lower TBW for weight and body surface area (BSA) as compared to normal weight individuals
Summary
Estimation of total body water (TBW) is integral to clinical care. It has significant implications for patient care that include dosing of medications, assessment and treatment of dehydration, fluid and energy requirements for parenteral nutrition, and dialysis prescriptions. There are several methods for body water estimation [3,4,5,6,7]. The isotope dilution technique is considered as sufficiently accurate and is used as a reference method for body water estimation. Estimation of total body water (TBW) is essential for clinical care. Editor: Mauro Lombardo, San Raffaele Roma Open University, ITALY
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