Abstract
Small animal PET scanning is destined to offer programs of the pre-clinical development of paradigms and protocols that are translatable for undertaking “systems biology” research in humans using total body PET Scanning.
Highlights
Positron emission tomography (PET) is the most specific and sensitive method for imaging regional tissue molecular interactions and pathways in humans [1]
The sensitivity for detecting low mass, i.e., truly tracer levels of biomarkers arises through: i) radiolabeling procedures that provide high specific activity of the tracer compound, ii) the use of imaging based upon coincident detection which offers highly efficient, electronic collimation for recording regional tissue concentrations of tracer
Preclinical small animal PET scanners arose both from the need to support the preclinical development of imaging biomarkers and the advances initially made to maximize the use of electronic collimation in humans
Summary
Positron emission tomography (PET) is the most specific and sensitive method for imaging regional tissue molecular interactions and pathways in humans [1]. Initial clinical research and healthcare applications of PET focused on individual organs of the body e.g., brain or heart and oncology focused on static [18F]FDG imaging for tumor detection within the torso.
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