Abstract
Total body irradiation (TBI), in combination with chemotherapy which is most often cyclophosphamide, is widely used since it was introduces in the fifties by E.D.Thomas as a preparatory regimen before bone marrow transplant. Even if it is an important part for conditioning regimen for patients with acute myeloid leukemia (AML) or acute lymphoid leukemia (ALL) undergoing hematopoietic stem cell transplantation, it is responsible for many side effects. New irradiation technique, tomotherapy and VMAT achieved a significant dose reduction to the OARs and the feasibility of dose escalation in a BMT conditioning regimen.
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