Total and regional microfiber transport characterization in a 15th - Generation human respiratory airway

Abstract

Fiber transport and deposition in the complete respiratory airway is of great significance for human health risk assessment. Thus far, the literature has mainly focused on limited branches of the upper airway and assumes spherical particles by neglecting fiber anisotropy. To fill the gap, this paper utilized an extended realistic respiratory airway from the nasal cavity to the distal bronchial tracts, up to the 15th generation. Fibers with aerodynamic diameters from 2 to 12 μm and aspect ratios of 1, 10, and 50 were released at the inlet of the respiratory airway model, and the coupled translational and rotational motion were computed. Overall and regional fiber deposition fractions, including the nasal cavities, laryngeal airway, and lungs were predicted and compared with earlier numerical results. The study also investigated: 1) secondary flow and distributions of the fibers at the lower respiratory airway entrance; 2) upstream conditions toward fiber deposition efficiencies; 3) fiber deposition patterns and detailed deposition fractions in the five lobes. Utilizing the realistic fiber transport model, the current study found that the upstream airway geometry and the flow condition have a significant impact on the fiber transport and deposition in the downstream airway regions. The fiber depositions in the lower and middle lobes are sensitive to the fiber aerodynamic diameter, but insensitive in the upper lobes. This study expects to generate innovative knowledge on the unique fiber motion characteristics toward potential inhalation health risks.