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Abstract
ObjectivesTORCH infections caused by Toxoplasma gondii (TOX), rubella virus (RV), cytomegalovirus (CMV) and herpes simplex virus 1,2 (HSV-1,2) are associated with congenital anomalies. The study aimed to analyze the characteristics of TORCH screening in reproductive age women.MethodsA total of 18,104 women (2015–2017) from a teaching hospital in Xi’an, China, were enrolled in the study. The characteristics of TORCH screening, i.e., the application of TORCH test, the seroprevalence, the impact of age, periods of gestation and woman with bad obstetric history (BOH) on the serological data were investigated.ResultsIn the study, 319 women (1.76%) performed dynamic TORCH test. 51.66, 20.44 and 3.83% of the population did the test in the pre-gestation period, the first and third trimester, respectively. Quite a few pre-gestation women (29.74%) ignored screening of IgG antibodies. The overall IgG/IgM seropositvity of TOX, RV, CMV, HSV-1 and HSV-2 was 4.35%/0.35, 90%/0.63, 96.79%/0.97, 81.11%/0.14 and 6.1%/0.19%, respectively. The age-specific distributions and periods of gestation had no significant effect on the seroprevalence of TORCH agents, p>0.05. However, BOH was significantly associated with higher seropositvity of IgM (RV, CMV, HSV-1 and HSV-2) and IgG (CMV and HSV-1) antibodies, p < 0.05.ConclusionIn Xi’an region, more attentions should be paid to TOX, CMV, HSV-2 and the women with BOH for TORCH screening. Meanwhile, a greater emphasis needs to be placed on TORCH test used inappropriately in China.
Highlights
TORCH infections, which called perinatal or congenital infections, are caused by serial organisms during pregnancy with an acronym TORCH, which named Toxoplasma gondii (TOX), Other, Rubella virus (RV), Cytomegalovirus (CMV), and Herpes Simplex Virus (HSV) [1,2,3]
Only CMV and HSV-2 PCR tests were approved for clinical practice by the China Food and Drug Administration (CFDA)
The habitual abortion, infertility and spontaneous abortion accounted for the majority of the women with bad obstetric history (BOH) (56.89, 27.77 and 12.46%, respectively)
Summary
TORCH infections, which called perinatal or congenital infections, are caused by serial organisms during pregnancy with an acronym TORCH, which named Toxoplasma gondii (TOX), Other (hepatitis viruses, parvovirus, human immunodeficiency virus, EpsteinBarr virus, syphilis), Rubella virus (RV), Cytomegalovirus (CMV), and Herpes Simplex Virus (HSV) [1,2,3]. The diagnosis and management of other TORCH infections, i.e., hepatitis viruses, syphilis and human immunodeficiency virus, are clear and highly efficacious. Most of the TORCH infections, such as TOX, RV, CMV and HSV, which are overlooked and difficult to. The present study was carried out to investigate the application and epidemiological characteristics of TOX, RV, CMV and HSV screening in reproductive age women from Xi’an region, China.
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