Abstract
Michael N. Hall is this year's recipient of the Lasker Basic Medical Research Award for the identification of the target of rapamycin, TOR. TOR is a master regulator of the cell's growth and metabolic state, and its dysregulation contributes to a variety of diseases, including diabetes, obesity, neurodegenerative disorders, aging, and cancer, making the TOR pathway an attractive therapeutic target.
Highlights
TOR is a master regulator of the cell’s growth and metabolic state, and its dysregulation contributes to a variety of diseases, including diabetes, obesity, neurodegenerative disorders, aging, and cancer, making the TOR pathway an attractive therapeutic target
That was to come from the identification of two novel and related mutants identified in the screen that were named TOR1 and TOR2, for targets of rapamycin
The TOR mutations identified in the yeast genetics screen are in a single codon that is required for FKBP12-rapamycin binding to and inhibition of TOR
Summary
TOR is a master regulator of the cell’s growth and metabolic state, and its dysregulation contributes to a variety of diseases, including diabetes, obesity, neurodegenerative disorders, aging, and cancer, making the TOR pathway an attractive therapeutic target. The TOR mutations identified in the yeast genetics screen are in a single codon that is required for FKBP12-rapamycin binding to and inhibition of TOR.
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