Abstract
Biodegradable polymer multi-layer drug delivery microstructure with micro-chambers has some unique advantages in controlled long-term drug delivery, which can enclose drug in the chambers to realize drug release in a controlled fashion. Therefore, it is necessary to obtain the optimal designs of the micro-chambers and their distributions. In this paper, topology optimization of a three-dimensional biodegradable polymer multi-layer drug delivery microstructure was carried out using the cellular automaton (CA)-based evolutionary structural optimization method. The results show that the optimized controlled release system exhibits a preferable linear drug release profile.
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