Topology optimization of the electrodes in dielectrophoresis-based devices

Abstract

This paper aims for developing topology optimization methodology to design the shape of electrodes in Dielectrophoresis (DEP)-based devices. The DEP force is due to a non-uniform electric field induced by applied voltages to the electrodes. Shape of the electrodes has the principal effect on the direction and magnitude of the DEP force. In medical therapy microfluidic devices, DEP force is used for cell sorting and cell separation. While the direction and magnitude of the DEP force are desired to be determined and maximized respectively, the magnitude of the electric field should be minimized to avoid damaging cells. Approaching these goals is counter intuitive where the existing electrode designs are basic. Therefore, a detailed finite element model (FEM) is developed for DEP force and electric field to formulate an optimization problem to maximize the DEP force in a particular direction while there is a constraint on electric field's magnitude. Using the developed FEM, explicit formulations for sensitivity analysis are derived to implement a gradient-based topology optimization. The performance of developed methodology is assessed numerically to determine the direction of the DEP force and constraining the electric field and experimentally in a practical case study of particle trapping in a microfluidic channel.