Abstract
Objective To analyze the topological properties of genomic-wide genetic interaction network in yeast.Methods The topological properties of genomic-wide genetic interaction network in yeast were calculated by the graph theory.Results A power law fit the degree distribution well in the genomic-wide genetic interaction network in yeast,with the exponent approaching 3.The Node's degree followed a wide-tail distribution,with the average degree being 87.Two thirds of the genes had genetic interaction via only one gene,and about one third of the genes had genetic interaction via only 2 genes.The average clustering coefficient was 0.047.Conclusion The gene function in yeast is usually multiple and the functional interaction between genes is highly condensed.
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