Abstract
The spatial scale of MEC spatial representations progressively increases along the dorsal-ventral axis, corresponding with a functional dissociation of dorsal versus ventral regions in supporting spatial learning. Here, we report the presence of a dorsal-ventral gradient in the temporal spiking dynamics (i.e. bursting) of MEC grid cells in behaving mice. This gradient in bursting supports the emergency of a dorsal grid cell population with a high signal-to-noise ratio, with bursting corresponding with increased spatial coherence and higher spatial fidelity at fast running speeds. In vitro recordings combined with a computational model points to a role for gradients in the intrinsic properties of MEC cells in supporting the gradient in bursting in vivo. Taken together, our results reveal a behaviorally relevant organization in the spatial and temporal coding features of MEC cells.
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