Abstract
Background & Objectives: Dyspepsia is a relatively common clinical condition characterized by chronic / recurrent upper abdominal pain or discomfort and is often associated with one or more of following symptoms at any given time - upper abdominal pain, burning sensation in the chest or upper abdomen, regurgitation, anorexia and early satiety. The present study was done to estimate the prevalence of Intestinal Metaplasia (IM) in the stomach in unselected patients with dyspepsia and to correlate these changes with symptoms, risk factors and endoscopic findings. Methods: We evaluated 102 patients who presented with symptoms of dyspepsia. Relevant clinical details were noted. A minimum of 9 endoscopic mucosal biopsies were taken from all subjects and in addition, biopsies were also taken from endoscopically abnormal areas. Rapid Urease Test (Standard in-house method) was done. All gastric biopsies were graded according to the Updated Sydney System. Statistical analysis was done using Chi-square test. Results: Intestinal metaplasia (IM) was seen in 16.7% of the patients, predominantly in the antrum (10.8%) and all of them showed Type II IM. Atrophic gastritis was again seen predominantly (65.2%) in the gastric antrum and these patients had significantly less (P=0.0065) H. pylori infection. Reflux symptoms were significantly less in patients with IM. Conclusion: We found a prevalence rate of 16.7% of Type II Intestinal Metaplasia of the stomach, which was topographically preponderant in the antrum.
Highlights
Dyspepsia is a relatively common clinical condition characterized by chronic / recurrent upper abdominal pain or discomfort and is often associated with one or more of the following symptoms at any given time – upper abdominal pain, burning sensation in the chest or upper abdomen, upper abdominal fullness or bloating, nausea, belching, regurgitation, anorexia and early satiety [1].Dyspepsia is a convenient descriptor for upper GI symptoms, but is a marker for structural diseases like malignancy, peptic ulcer disease, gastritis etc
Among them the commonest abnormality was erythematous gastritis which was seen in 43 patients, followed by duodenal ulcer in 15 patients, erosive gastritis in 14 patients, gastric ulcer in 3 patients, esophageal candidiasis in 4 patients and carcinoma stomach in 1 case
When the symptom positive patients are compared with the presesnce of Intestinal Metaplasia, around 17 (16.7%) were IM positive, and 85 (83.3%) were IM negative patients (Figure 1)
Summary
Dyspepsia is a relatively common clinical condition characterized by chronic / recurrent upper abdominal pain or discomfort and is often associated with one or more of the following symptoms at any given time – upper abdominal pain, burning sensation in the chest or upper abdomen, upper abdominal fullness or bloating, nausea, belching, regurgitation, anorexia and early satiety [1].Dyspepsia is a convenient descriptor for upper GI symptoms, but is a marker for structural diseases like malignancy, peptic ulcer disease, gastritis etc. Dyspepsia is a relatively common clinical condition characterized by chronic / recurrent upper abdominal pain or discomfort and is often associated with one or more of the following symptoms at any given time – upper abdominal pain, burning sensation in the chest or upper abdomen, upper abdominal fullness or bloating, nausea, belching, regurgitation, anorexia and early satiety [1]. Several classification systems have been used, but the one most widely employed is that proposed by Jass & Filipe [2] According to this classification, intestinal metaplasia is classified into complete and incomplete types. Dyspepsia is a relatively common clinical condition characterized by chronic / recurrent upper abdominal pain or discomfort and is often associated with one or more of following symptoms at any given time upper abdominal pain, burning sensation in the chest or upper abdomen, regurgitation, anorexia and early satiety. Conclusion: We found a prevalence rate of 16.7% of Type II Intestinal Metaplasia of the stomach, which was topographically preponderant in the antrum
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