Topographic Relationships among Deep Optic Nerve Head Parameters in Patients with Primary Open-Angle Glaucoma

Do-Young Park,Hoon Noh,Changwon Kee,Jong-Chul Han

doi:10.3390/jcm11051320

Do-Young Park, Hoon Noh + Show 2 more

Open Access

https://doi.org/10.3390/jcm11051320

Copy DOI

Abstract

Purpose: To investigate the topographic relationships among the deep optic nerve head (ONH) parameters representing myopic axial elongation or changes in the lamina cribrosa (LC) in patients with primary open-angle glaucoma (POAG). Methods: Among patients with POAG who visited the clinic between January 2015 and March 2017, the following deep ONH parameters were measured using spectral-domain optical coherence tomography (SD-OCT): externally oblique border tissue (EOBT) length, ONH tilt angle, optic canal (OC) obliqueness, and anterior LC insertion depth (ALID). In addition, the angular locations of the maximal value of each parameter were measured. We analyzed the correlations between the parameters, correlations with axial length (AL), and the spatial correspondence with glaucomatous ONH damage. Results: A total of 100 eyes with POAG were included in the analysis. The EOBT length, ONH tilt angle, and OC obliqueness were correlated with each other and with AL, whereas ALID showed less correlation with the other parameters and AL. The angular location where the three AL-related parameters had maximum values was also correlated with the predominant region of the glaucomatous ONH damage, while the angular location of the deepest ALID showed less correlation. Conclusions: Among the deep ONH parameters, the AL-related parameters EOBT length, ONH tilt angle, and OC obliqueness showed strong spatial correspondence with glaucomatous ONH damage, whereas the LC-related parameter ALID was less correlated with both AL and the region with glaucomatous ONH damage. Further studies are needed to determine how these differences affect glaucomatous ONH change.

Highlights

100 eyes from deep optic nerve head (ONH) parameters except for anterior LC insertion depth (ALID) were significantly inferiorly located in the superior dominant VF group compared with the inferior dominant VF defect group
When the angular locations were divided by binary values of positive and negative directions relative to the FoBMO axis, the binary values of the locations of all maximum deep ONH parameters were significantly associated with the dominant location of the VF defect
We analyzed the characteristics of four deep ONH parameters measured by spectral-domain optical coherence tomography (SD-optical coherence tomography (OCT)) in patients with primary open-angle glaucoma (POAG) in terms of correlations between the parameters, correlations with axial length (AL), and spatial correspondence with the glaucomatous ONH damage

Summary

Introduction

The EOBT length, ONH tilt angle, and OC obliqueness were correlated with each other and with AL, whereas ALID showed less correlation with the other parameters and AL. The angular location where the three AL-related parameters had maximum values was correlated with the predominant region of the glaucomatous ONH damage, while the angular location of the deepest ALID showed less correlation. Conclusions: Among the deep ONH parameters, the AL-related parameters EOBT length, ONH tilt angle, and OC obliqueness showed strong spatial correspondence with glaucomatous ONH damage, whereas the LC-related parameter ALID was less correlated with both AL and the region with glaucomatous ONH damage. We measured deep ONH parameters including externally oblique border tissue (EOBT) length, ONH tilt angle, and optic canal (OC) obliqueness and found that these characteristics were associated with the presence of glaucoma and the location published maps and institutional affiliations

Methods

Results

Conclusion