Abstract
The central stimulating action of Coffein was electrophysiologically investigated on the conscious rabbit. Coffein induces, like most central stimulating drugs, an electrographic arousal pattern. In opposition to most central acting stimulating drugs investigated up to now, its action remains detectable in the so called „cerveau isole“. Activation of the ascending reticular system by coffein could not be demonstrated, but a definite decrease in excitability of the intralaminary medio-thalamic recruiting system could be ascertained. Since this system develops apparently a moderating action on the cortex, this suppression of a thalamic inhibitory function explains the stimulating action of coffein on behaviour, as well as activation of the cortex, with its typical electrographic pattern (desynchronization of the basic cortical rhythm, suppression of spindles activity and decrease of the recruiting cortical response elicited by stimulation of the mediothalamic recruiting system). Since coffein develops its stimulating action by means of a mediothalamic inhibition and not by activation of the ascending reticular system, this drug belongs to a group of psychotonic1 drugs, which has not yet been specified.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Naunyn-Schmiedebergs Archiv f�r Experimentelle Pathologie und Pharmakologie
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
