Topics in Pathophysiology of Hypertension

Abstract

I. Transport Across Membranes and Hypertension.- Introduction: Membrane transport.- Biomembrane abnormalities in spontaneous hypertension.- Erythrocyte Na+ handling in rat genetic hypertension.- Ca2+ binding by the erythrocyte membrane and its structure in primary and secondary hypertension.- Calmodulin-dependent calcium transport in erythrocytes in primary hypertension.- The Na+/K+ co-transport system in erythrocytes from essential hypertensive patients.- Sodium, lithium and potassium co- and countertransport in erythrocytes and its relation to essential hypertension.- Familial aggregation of sodium countertransport and co-transport and essential hypertension.- Red cell sodium-lithium countertransport in hypertension.- Hypertension: multiple membrane malfunctions.- Preliminary analysis of sodium-lithium countertransport and blood pressure in Utah pedigrees.- Cation transport abnormalities in human and rat essential hypertension.- The sodium-lithium exchange mechanism in essential hypertension: is it a sodium/proton exchanger?.- Ouabain-sensitive and -insensitive cation transport in normotensives and hypertensives in hypokalemic states.- Presynaptic ?-autoreceptors: pharmacological properties and physiological function.- The effects of DIDS and anion substitution on aortic 36Cl turnover in aldosterone-induced hypertensive rats.- Function of the sodium pump in vascular smooth muscle in hypertension.- Evidence against raised intracellular sodium causing myogenic contraction in rat resistance vessels.- Role of an ouabain-like humoral agent and the sodium-potassium pump in low-renin hypertension.- An increase in a circulating inhibitor of Na+/K+-ATPase: the link between sodium and vascular tone in experimental and inherited hypertension?.- The role of sodium-calcium exchange in the genesis of essential hypertension.- II. Neural Control of Blood Pressure.- Introduction: Neural control.- Evidence for the participation of specific hypothalamic pathways in the pathogenesis of hypertension.- Neuropeptides in the central regulation of blood pressure.- The role of various afferents in the regulation of sympathetic tone in hypertension: a brief review.- Defects in signal generation in arterial baroreceptors.- Influence of sodium intake on the neurogenic contribution in hypertension.- Some aspects of cardiovascular nervous control in spontaneously hypertensive rats: central and peripheral mechanisms.- Pre- and postsynaptic receptors in hypertensive states.- Electrical events of vascular smooth muscle in response to ?1-adrenoceptor stimulation.- III. Recent Advances in Research on Renin System.- Studies of renin biosynthesis and release.- Molecular cloning of submaxillary renin cDNA.- Primary structure of mouse submaxillary gland renin.- Purification of prorenin.- Extrarenal renin-angiotensin system: comments on its occurrence and cardiovascular role.- Studies on the purification and characterization of human angiotensinogen.- Enzymatic studies with renin substrate.- The brain renin-angiotensin system: problems and answers.- IV. Renal, Adrenal and Central Hormones in Hypertension.- A bipolar analysis of blood pressure phenomena: the vasoconstriction and volume factors in normotension and in the spectrum of hypertensive disorders as revealed by renin-sodium profiling or pharmacologic probes: prorenin as a determinant of renin secretion.- Regulation of blood pressure by vasopressin.- The renomedullary interstitial cells in hypertension.- The pituitary and hypertension.- Stress, ACTH, and hypertension.- Mineralocorticoids in hypertension: 19-nor-corticosteroids in experimental and human hypertension.- Renal and CNS factors in NaCl-induced hypertension.