Abstract
Abstract Objective To evaluate the adjuvant treatment of acute stage symptoms and quality of life of patients with bullous pemphigoid (BP) with ozone. Methods We included 74 patients with moderate and severe BP hospitalized from July 2018 to December 2020. The participants were randomly divided into the control group and the ozone group, with 37 patients in each group (n = 37). The control group used tap water to wash the whole body, and mupirocin ointment was used for the erosions. The ozone group used ozone water to wash the whole body, and the erosion place was coated with ozone oil. The bullous pemphigoid disease area index (BPDAI) score of BP disease was used to observe the clinical symptoms and skin lesions of the two groups before and on day 3, 7, and 14 after treatment. Pruritus and sleep were observed before and on day 3, 7, and 14 after treatment. The Dermatology Life Quality Index (DLQI) was used to observe the quality of life before and after treatment and the adverse reactions were recorded. Results The total BPDAI score and erythema score in the ozone group were significantly different from those in the control group on day 3, 7, and 14 after treatment (P < 0.050). The scab drying time and erosion drying time of ozone group were shorter than that of control group (P < 0.001). There were statistically significant differences between the ozone group and the control group in pruritus score and sleep score on day 3, 7, and 14 after treatment (P < 0.001). There was statistically significant difference in skin disease quality of life between the two groups 14 days after treatment (P < 0.001). No significant adverse reactions and complications were observed in both groups. Conclusions Ozone external use can rapidly improve the acute stage of edema erythema, erosion, and itching of BP, improve the quality of life of patients, is an effective treatment method, and worthy of clinical promotion.
Highlights
IntroductionThe mortality rate of bullous pemphigoid (BP) patients in the first year was as high as 6–41%, which was 12.9% in China.[3,4,5,6,7] At present, the majority of patients at home and abroad adopt topical glucocorticoids ointment combined with low-dose oral glucocorticoid to treat moderate and severe BP
Ozone external use can rapidly improve the acute stage of edema erythema, erosion, and itching of bullous pemphigoid (BP), improve the quality of life of patients, is an effective treatment method, and worthy of clinical promotion
It was reported that the mortality rate of BP patients in the first year was as high as 6–41%, and 12.9% in China.[3,4,5,6,7]
Summary
The mortality rate of BP patients in the first year was as high as 6–41%, which was 12.9% in China.[3,4,5,6,7] At present, the majority of patients at home and abroad adopt topical glucocorticoids ointment combined with low-dose oral glucocorticoid to treat moderate and severe BP. It has been found in clinical practice that for patients with severe erosive exudation and with or without bacterial skin infection, topical glucocorticoid ointment could not achieve satisfactory therapeutic effects
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