Abstract
Objective: To systematically identify the effectiveness of the topical use of green propolis in the healing process of surgical wounds. Methods: Systematic review of the literature that considered the publications available in the databases: National Library of Medicine(PubMed/MEDLINE), LatinAmerican and Caribbean Health Sciences Literature (LILACS), The Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science. The risk of bias of the studies was analyzed using the Systematic Review Centre for Laboratory animal Experimentation (SYRCLE) tool. Results: The four studies analyzed used green propolis for the healing of surgically made lesions. All the selected studies were of experimental methodology, performed with animals. Two studies (50%) used the ethanolic extract of green propolis (at concentrations of 2.4% and 20%) and the other two studies (50%) used the hydroalcoholic extract of green propolis at 5.0%. Conclusion: The results showed that the topical use of formulated products based on green propolis promoted the healing of skin lesions, since it favored angiogenesis, the proliferation of fibroblasts and, consequently, the synthesis and deposition of collagen, as well as showed antimicrobial activity and showed.
Highlights
Propolis is a resin produced by bees and has been used since ancient times as a medicine to treat skin lesions or other ailments
Considering the complexity involved in the treatment of different skin lesions, the present study aimed to systematically identify the effectiveness of the topical use of green propolis in the healing process of surgical wounds in animals. This is a systematic review of the literature, whose report adopted the criteria established by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) and its protocol was registered in International Prospective Register of Systematic Reviews (PROSPERO), with number CRD4202018790420,21
The results showed an increase in the cells present in the inflammatory and proliferative phases of healing, indicating the satisfactory action of the product in the process of tissue repair
Summary
Propolis is a resin produced by bees and has been used since ancient times as a medicine to treat skin lesions or other ailments. Bees collect exudates from trees, plants, leaves and the pollen of various flowers which, associated with the salivary secretions of these insects, form the resinous material[1,2]. Its botanical origin is mainly the Baccharis dracunculifolia DC, popularly known as “alecrim-do-campo” and “vassourinha”. This type of propolis is composed of flavonoids, prenylated derivatives of p-coumaric acid, artepillin C, diterpenes, and triterpenes, among others. It is commercialized in natura, in the form of extracts, gels, ointments, oils, shampoos, or associated with other compounds[2-4]
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