Topical use of DEET insect repellent as a cause of severe encephalopathy in a healthy adult male.

Abstract

Academic Emergency MedicineVolume 6, Issue 12 p. 1295-1297 Free Access Topical Use of DEET Insect Repellent as a Cause of Severe Encephalopathy in a Healthy Adult Male Louis C. Hampers MD, MBA, Louis C. Hampers MD, MBA Section of Pediatric Emergency Medicine, The Children's Hospital, Denver, COSearch for more papers by this authorElif Oker MD, Elif Oker MD Department of Emergency Medicine, University of Illinois at Chicago, and Cook County Hospital/Toxicon Consortium, Chicago, ILSearch for more papers by this authorJerrold B. Leikin MD, Jerrold B. Leikin MD Cook County Hospital/Toxicon Consortium, and Department of Internal Medicine, Rush-Presbyterian-St. Luke's Medical Center, Chicago, ILSearch for more papers by this author Louis C. Hampers MD, MBA, Louis C. Hampers MD, MBA Section of Pediatric Emergency Medicine, The Children's Hospital, Denver, COSearch for more papers by this authorElif Oker MD, Elif Oker MD Department of Emergency Medicine, University of Illinois at Chicago, and Cook County Hospital/Toxicon Consortium, Chicago, ILSearch for more papers by this authorJerrold B. Leikin MD, Jerrold B. Leikin MD Cook County Hospital/Toxicon Consortium, and Department of Internal Medicine, Rush-Presbyterian-St. Luke's Medical Center, Chicago, ILSearch for more papers by this author First published: 28 June 2008 https://doi.org/10.1111/j.1553-2712.1999.tb00147.xCitations: 13AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat References 1 Osimitz T. G., Murphy J. V.. Neurological effects associated with use of the insect repellent N, N-diethyl-m-toluamide (DEET). J. Toxicol Clin Toxicol. 1997; 35: 435– 41. 2 Tenebein M.. Severe toxic reactions and death following the ingestion of diethyltoluamide-containing insect repellents. JAMA. 1987; 258: 1509– 11. 3 Gryboski J., Weinstein D., Ordway N. K.. Toxic encephalopathy apparently related to the use of an insect repellent. N Engl J Med. 1961; 264: 289– 91. 4 Zadikoff C. M.. Toxic encephalopathy associated with use of insect repellent. J Pediatr. 1979; 95: 140– 2. 5 Heick HMC, Shipman R. T., Norman M. G., et al. Reye-like syndrome associated with use of insect repellent in a presumed heterozygote for ornithine carbamoyl transferase deficiency. J Pediatr. 1980; 97: 471– 3. 6 De Garbino J. P., Laborde A.. Toxicity of an insect repellent: N, N-diethyl-m-toluamide. Vet Hum Toxicol. 1983; 25: 422– 3. 7 Roland E. H., Jan J. E., Rigg M. J.. Toxic encephalopathy in a child after brief exposure to insect repellents. Can Med Assoc J. 1985; 132: 155– 6. 8 Snyder J. W., Poe R. O., Stubbins J. F., et al. Acute manic psychosis following the dermal application of N, N-diethyl-m-toluamide (DEET) in an adult. J Toxicol Clin Toxicol. 1986; 24: 429– 39. 9 Edwards C. E., Johnson J. E.. Insect-repellent-induced toxic encephalopathy in a child. Clin Pharmacol. 1987; 6: 496– 8. 10 Oransky S., Roseman B., Fish D., et al. Seizures temporally associated with use of DEET insect repellent—New York and Connecticut. MMWR. 1989; 38: 678– 80. 11 Lipscomb J. W., Kramer J. E., Leikin J. B.. Seizure following brief exposure to the insect repellent N, N-diethyl-m-toluamide. Ann Emerg Med. 1992; 21: 315– 7. 12 Garrettson L.. DEET: caution for children still needed [commentary]. J Toxicol Clin Toxicol. 1997; 35: 443– 5. 13 Clem J. R., Havermann D. F., Raebel M. A.. Insect repellent (N, N-diethyl-m-toluamide) cardiovascular toxicity in an adult. Ann Pharmacother. 1993; 27: 289– 93. 14 Selim S., Hartnagel R. E., Osimitz T. G., et al. Absorption, metabolism, and excretion of N, N-diethyl-m-toluamide following dermal application to human volunteers. Fundam Appl Toxicol. 1995; 25: 95– 100. 15 Leikin J. B., Paloucek F. P.. Poisoning and Toxicology Compendium. Cleveland , OH : Lexi-Comp Inc., 1995, pp 677– 8. 16 Fraser A. D., MacNeil A., Theriault M., et al. Analysis of diethyltoluamide (DEET) following oral ingestion of Muscol. J Anal Toxicol. 1995; 19: 197– 9. 17 Promotional pamphelet: What you should know about natural disasters:important information and prevention tips from the Off Biting Insect Center. Racine, WI: S.C. Johnson & Son, Inc., 1997. Citing Literature Volume6, Issue12December 1999Pages 1295-1297 ReferencesRelatedInformation