Abstract
BackgroundGallium is a semi-metallic element known since the 1930s to have antimicrobial activity. This activity stems primarily from gallium's ability to mimic trivalent iron and disrupt specific Fe(III)-dependent pathways, particularly DNA synthesis (due to inhibition of ribonucleotide reductase). Because of its novel mechanism of action, gallium is currently being investigated as a new antibacterial agent, particularly in light of the increasing resistance of many pathogenic bacteria to existing antibiotics. Gallium maltolate (GaM) is being developed as an orally and topically administrable form of gallium. Yaws is a neglected tropical disease affecting mainly the skin and skeletal system of children in underprivileged settings. It is currently the object of a WHO-promoted eradication campaign using mass administration of the macrolide azithromycin, an antibiotic to which the yaws agent Treponema pallidum subsp. pertenue has slowly begun to develop genetic resistance.MethodsBecause yaws transmission is mainly due to direct skin contact with an infectious skin lesion, we evaluated the treponemicidal activity of GaM applied topically to skin lesions in a rabbit model of yaws. Treatment efficacy was evaluated by measuring lesion diameter, treponemal burden in lesion aspirates as determined by dark field microscopy and amplification of treponemal RNA, serology, and immunohistochemistry of biopsied tissue samples.ResultsOur results show that topical GaM was effective in reducing treponemal burden in yaws experimental lesions, particularly when applied at the first sign of lesion appearance but, as expected, did not prevent pathogen dissemination.ConclusionEarly administration of GaM to yaws lesions could reduce the infectivity of the lesions and thus yaws transmission, potentially contributing to current and future yaws control campaigns.
Highlights
BackgroundGallium is a semi-metallic element known since the 1930s to have antimicrobial activity
Yaws is a neglected tropical disease (NTD) [1,2] caused by the spirochete bacterium Treponema pallidum subsp. pertenue (Tp pertenue), a pathogen closely related to the syphilis agent, Treponema pallidum subsp. pallidum (Tp pallidum) [3]
Our results show that topical Gallium maltolate (GaM) was effective in reducing treponemal burden in yaws experimental lesions, when applied at the first sign of lesion appearance but, as expected, did not prevent pathogen dissemination
Summary
Gallium is a semi-metallic element known since the 1930s to have antimicrobial activity. This activity stems primarily from gallium’s ability to mimic trivalent iron and disrupt specific Fe(III)-dependent pathways, DNA synthesis (due to inhibition of ribonucleotide reductase). Because of its novel mechanism of action, gallium is currently being investigated as a new antibacterial agent, in light of the increasing resistance of many pathogenic bacteria to existing antibiotics. Yaws is a neglected tropical disease affecting mainly the skin and skeletal system of children in underprivileged settings. It is currently the object of a WHO-promoted eradication campaign using mass administration of the macrolide azithromycin, an antibiotic to which the yaws agent Treponema pallidum subsp. It is currently the object of a WHO-promoted eradication campaign using mass administration of the macrolide azithromycin, an antibiotic to which the yaws agent Treponema pallidum subsp. pertenue has slowly begun to develop genetic resistance
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