Abstract
Inherited epidermolysis bullosa is a group of genetic skin disorders characterized by skin erosions, ulceration, skin and mucosal blistering requiring topical treatment. This review demonstrates major clinical manifestations of epidermolysis bullosa and its mechanisms of development. According to these features the main principles of topical treatment and drug therapy were developed, including physical protection from trauma, moisturizing, improvement of wound healing, prevention and management of infection, itch and pain management. Drug therapy is outlined with dosage forms, drug routes of administration, age restrictions indicated in the instruction for medical use for the medications that could be used in epidermolysis bullosa patients. The authors provide indications for clinical use of antiseptics, disinfectants, antibiotics, antimicrobial agents, emollient cream and drugs reducing itch and pain.
Highlights
Ключевые слова: врожденный буллезный эпидермолиз, наружная терапия, препараты для лечения ран и язв, антисептики, дезинфицирующие средства, антибиотики, противомикробные средства
Inherited epidermolysis bullosa is a group of genetic skin disorders characterized by skin erosions, ulceration, skin and mucosal blistering requiring topical treatment
This review demonstrates major clinical manifestations of epidermolysis bullosa and its mechanisms of development
Summary
Ключевые слова: врожденный буллезный эпидермолиз, наружная терапия, препараты для лечения ран и язв, антисептики, дезинфицирующие средства, антибиотики, противомикробные средства. For citation: Kubanov АA, Chikin VV, Karamova AE, Monchakovskaya ES. Ретинол для устранения сухости кожи у больных врожденным буллезным эпидермолизом применяется в форме 0,5% мази для наружного применения (Видестим).
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