Topical therapy drugs containing silver in acute adenoiditis sinusitis in children

Abstract

The article presents the results of Russian authors’ research aimed at studying the clinical efficacy of topical drugs containing silver in treating acute serous adenoiditis and sinusitis in children. The authors noted the efficacy and safety of the drug (silver proteinate and polyvinyl-N-pyrrolidone) in the complex treatment of inflammatory diseases of the nose and paranasal sinuses in children. Clinical observation was carried out – comparison of two groups of 30 patients aged from 5 to 14 years, average age 6 years 3 months, the groups included: 17 boys (56.7%) and 13 girls (43.3%), all children had adenoid vegetations of the 1st-2nd degree. To assess the clinical efficacy of the drug, a control group of children with similar pathology was recruited, comparable in age and sex (14 boys and 16 girls). The main group received the drug Sialor and irrigation therapy. The control group received local antibacterial drugs and decongestants according to age. At the beginning of treatment normal values of mucociliary transport were not observed in any patient (0%) of the main and control groups. Disorder of the 1st degree mucociliary transport function was determined in 6 children (20%) of the main group and 7 children (23.3%) of the control group, 2nd degree – in 21 children (70%) of the main group and 19 children (63.3%) of the control group, 3rd degree – in 3 (10%) patients of the main group and 4 children (13.4%) of the control group. In 7 days from the beginning of treatment normal values of MCT were observed in 28 patients (93.3%) of the main group and 9 patients (30%) of the control group, the disorder of MCT function of the 1st degree had 3 patients (9%) of the main and control groups, the 2nd degree was not in the main group and was revealed in 18 patients (60%) of the control group, no disorder of MCT function of the 3rd degree was revealed (neither in the main nor control groups). The average time of MCT was: before treatment – 49 minutes (main group) and 47 minutes (control group), the 3rd day of treatment – 28 minutes (main group) and 36 minutes (control group). On the 7th day of the drug intake – 14 minutes (main group) and 21 minutes (control group). Thus, normalization of MCT time was noted only in patients of the main group. On the 7th day of treatment with Sialor in the main group of children under examination, nasal mucosa edema, nasal excretion and adenoid tissue size decreased, mucociliary transport parameters normalized, nasal breathing improved. Sialor has a pronounced anti-inflammatory and anti-edema effect, is well tolerated by patients and can be recommended for inclusion in standard treatment protocols of patients with diseases of the nasal cavity, paranasal sinuses.