Topical Stabilized Super-Oxidized Hypochlorous Acid for Wound Healing in Hair Restoration Surgery: A Real-Time Usage-Controlled Trial Evaluating Safety, Efficacy, and Tolerability.

Abstract

Assess the perceived efficacy of stabilized, super-oxidized hypochlorous acid (HOCl) in hair transplant surgical procedures intraoperative and postoperative. Stabilized, super-oxidized hypochlorous acid (HOCl) is highly effective against bacterial, fungal, and viral microorganisms. In addition, topical HOCl will increase tissue oxygenation of wound sites to aid in healing. This molecule represents an ideal agent for intraoperative and postoperative use in hair restoration procedures that involve thousands of small wounds. 35 patients were enrolled in a multi-site study following repeat or initial hair restoration surgery. Surgeons were provided a 500 mL trigger spray bottle of HOCl spray liquid for use prior to and throughout the surgical procedure. Patients were provided with a ten-day supply of HOCl for postoperative care. Two formulations were utilized, one was applied to the recipient sites while the other was applied to the donor area postoperatively. Patients and surgeons were provided with observational surveys regarding healing and usage of the products. Statistical analysis found 56% had significant reduction in the amount of erythema compared to their current wound healing regimen. More than half of the patients (54%) had significant improvement of pruritus. The compliance rating for this study was 97% among patients. Surgeons were queried on the overall efficacy. There were no incidences of donor or recipient tissue necrosis. The evolution of hair restoration surgery has been accompanied by large numbers of grafts being implanted. This change necessitates the requirement for optimum intraoperative and postoperative care. Topical, stabilized hypochlorous spray represents a major advance in wound cleansing and healing and offers the theoretical benefits of reducing tissue necrosis through oxygenation. J Drugs Dermatol. 2023;22(12):1191-1196. doi:10.36849/JDD.7172.