Abstract
To the Editor: Mucosal lesions greatly influence the quality of life in a substantial proportion of patients with pemphigus vulgaris (PV). Lesions are recurrent and frequently resistant to therapy. 1 Scully C. Paes De Almeida O. Porter S.R. Gilkes J.J. Pemphigus vulgaris: the manifestations and long-term management of 55 patients with oral lesions. Br J Dermatol. 1999; 140: 84-89 Crossref PubMed Scopus (125) Google Scholar Systemic corticosteroids may provide relief, but are often accompanied by debilitating systemic side effects. Therefore, not only the use of systemic steroid-sparing drugs is important, but also the search for effective nonsystemic topical therapies. We report the use of topical sirolimus in 3 patients with PV and predominant oral mucosal involvement.
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