Abstract
Only a few reports have been published on the use of topical antifungal prophylaxis [1-4]. For this reason we read with interest the paper published by Giglio and colleagues [5] underlining the ability of oral nystatin to reduce fungal colonization in surgical/trauma ICU patients. In our experience, we observed a dramatic increase of candidemia prevalence in neurosurgical ICU patients after implementation of early tracheostomy (from 2.2% to 9.7%). Following an analysis of data collected, we developed the idea that Candida colonization could spread by contiguity from the oropharynx to the trachea and the tracheostomy site. Th e proximity of the trache ostomy to the central venous catheter (CVC) insertion site could be considered a predisposing factor
Highlights
A few reports have been published on the use of topical antifungal prophylaxis [1,2,3,4]
*Correspondence: giancarlo.ceccarelli@uniroma1.it 1Department of Public Health and Infectious Diseases, University of Rome “Sapienza”, Italy Full list of author information is available at the end of the article
Our preliminary data add another aspect to this line of research: topical nystatin prophylaxis combined with improved central venous catheter (CVC) management resulted in a significant decrease in incidence of candidemia
Summary
A few reports have been published on the use of topical antifungal prophylaxis [1,2,3,4]. *Correspondence: giancarlo.ceccarelli@uniroma1.it 1Department of Public Health and Infectious Diseases, University of Rome “Sapienza”, Italy Full list of author information is available at the end of the article
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